Clinical Publications

TRITON

Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis

AUTHORS:

Garcia-Martin E, Jarauta L, Vilades E, Ara JR, Martin J, Polo V, Larrosa JM, Pablo LE, Satue M.

PUBLICATION:

Ophthalmol. 2018 Nov 13;2018:7361212. PMID: 30538857 DOI: 10.1155/2018/7361212

Study Purpose

To evaluate the ability of swept-source-OCY (SS-OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS).

Overview

Study Design

Observational, cross-sectional

# of Eyes/
Patients

• Ninety-seven eyes of 97 relapsingremitting multiple sclerosis(RRMS) and 101 eyes of 1010 healthy individuals.

Study Device

DRI Triton SS-OCT (Topcon, Tokyo, Japan)

Outcome Measures

• Macular (EDTRS, GCL+ and GCL++) and peripapillary (RNFL, GCL+, and GCL++) thickness. Choroidal thickness for both the macular (EDTRS) and peripapillary area (TSNIT).

Results

Mean age of RRMS patients and healthy individuals were 48.46 + 11.31 years and 47.58 + 9.37 years, respectively.
Mean disease duration in the patients was 7.56 + 2.66 years.
Measurements showed reduced retinal thickness in all macular ETDRS sectors with MS patients compared with controls (P

IMOvifa reduced measurement time by

39%

Conclusions

• Triton SS-OCT detected significant retinal thinning in all the ETDRS areas in our patients, as well as retinal and RNFL thinning in all sectors of the peripapillary measurement (except in the nasal quadrant/sector). • The authors suggest that the fact that the nasal quadrant is affected only in the GCL+ in their patients may suggest that GCL measurements are a subtle marker for neurodegeneration than RNFL. • SS-OCT device detects macular thinning and peripapillary retinal, RNFL, and GCL reduction in MS patients, providing increased and more detailed evaluation of the choroid in these patients