Clinical Publications

MAESTRO

Agreement and Precision of Wide and Cube Scan Measurements between Swept-source and Spectral-domain OCT in Normal and Glaucoma Eyes

AUTHORS:

Hou H, El-Nimri NW, Durbin MK, Arias JD, Moghimi S, Weinreb RN*

PUBLICATION:

Sci Rep. 2023 Sep 23;13(1):15876.

Study Purpose

To evaluate agreement of Wide scan measurements from swept-source optical coherence tomography (SS-OCT) Triton and spectral-domain OCT (SD-OCT) Maestro in normal/glaucoma eyes, and to assess the precision of measurements from Wide and Cube scans of both devices

Overview

Study Design

Prospective

# of Eyes/
Patients

25 normal eyes & 25 glaucoma eyes

Study Device

3D OCT-1 Maestro
DRI OCT Triton

Outcome Measures

Circumpapillary retinal nerve fiber layer (cpRNFL), macular ganglion cell layer + inner plexiform layer (GCL + IPL/abbreviated to GCL+), and ganglion cell complex (abbreviated to GCL++)

Results

GCL++ thickness measurements from both the wide scan and the macular cube scan on the Maestro showed CV within 1% for repeatability and reproducibility for both normal and glaucoma groups, with the exception of CV% of reproducibility for the Superior Nasal region in the Glaucoma group, which was 1.1%
GCL+ thickness measurements from both the wide scan and the macular cube scan on the Maestro showed CV within 1.1% for repeatability and reproducibility for the normal group RNFL thickness measurements from both the wide scan and the optic disc cube scan on the Maestro showed CV within 3.2% for repeatability and reproducibility for the normal group
RNFL thickness measurements from both the wide scan and the optic disc cube scan on the Maestro showed CV within 3.2% for repeatability and reproducibility for the normal group
Wide scan measurements from both devices have shown excellent agreement with each other (intercepts did not significantly differ from 0 and the slopes did not differ significantly from 1)
The differences between Triton and Maestro (mean difference of all measurements

IMOvifa reduced measurement time by

39%

Conclusions

• Wide scan measurements from both devices have shown excellent agreement with each other in both normal and glaucoma eyes. • Precision of cpRNFL, macular GCL+, and macular GCL++ thickness measurements from the Wide and the Macular/Optic Disc Cube scans were high and similar for both devices in normal and glaucoma eyes. • Measurement differences between Triton and Maestro are assumed to not be of clinical significance (mean difference below resolution in tissue). • Wide scans, including the ONH and the macula, may provide benefits for glaucoma diagnosis and management as they demonstrate interchangeable measurement and high precision.