Clinical Publications

TRITON

Agreement, repeatability, and reproducibility of quantitative retinal layer assessment using swept-source and spectral-domain optical coherence tomography in eyes with retinal diseases

AUTHORS:

Hou H, Durbin MK, El-Nimri N, Fischer JL and Sadda SR.

PUBLICATION:

Front Med (Lausanne). 2023 Dec 18; 10:10:1281751. DOI: 10.3389/fmed.2023.1281751

Study Purpose

To assess the agreement, repeatability, and reproducibility of retinal thickness measurements between swept-source OCT (SS-OCT) and spectral-domain OCT (SD-OCT) in healthy eyes and those with retinal diseases.

Overview

Study Design

Cross-sectional, prospective

# of Eyes/
Patients

• 25 eyes from 25 healthy subjects • 26 eyes from 26 patients with retinal diseases

Study Device

DRI OCT Triton™ (Topcon, Tokyo, Japan)
3D OCT-1 Maestro (Topcon, Tokyo, Japan)

Outcome Measures

• Retinal Thickness Measurements: full retina, GCL+, and GCL++ • Agreement: how closely the measurements from the two different OCT devices (SS-OCT and SD-OCT) aligned with each other • Repeatability: the consistency of measurements when repeated on the same eye under the same conditions using the same device • Reproducibility: the consistency of results across different operators and devices, ensuring that the measurements are reliable even when taken under varied conditions

Results

High Agreement: The study found excellent agreement between the SS-OCT (Triton) and SD-OCT (Maestro) devices for retinal thickness measurements, with mean differences between the devices being small (less than 6 μm) and not statistically significant.
Strong Repeatability: Both devices demonstrated high repeatability in retinal thickness measurements, with the repeatability limit of ≤7.6 μm for Triton and ≤12.7 μm for Maestro, and the repeatability coefficient of variation (CV%) being less than 2.6% for the Triton and less than 3.4% for the Maestro in eyes with retinal diseases.
Good Reproducibility: The reproducibility of the measurements was also strong across both devices, reproducibility limit was ≤9.2 μm for Triton and ≤14.4 μm for Maestro, and reproducibility CV% less than 3.3% for the Triton and less than 3.5% for the Maestro in pathologic eyes.

IMOvifa reduced measurement time by

39%

Conclusions

The Triton SS-OCT and Maestro SD-OCT devices are highly reliable for measuring retinal thickness, showing excellent repeatability and reproducibility in both healthy eyes and those with retinal diseases. • The close alignment between the measurements from these two devices confirms their effectiveness in clinical practice, ensuring consistent and accurate retinal assessments. • These OCT technologies may be used interchangeably in clinical settings, providing robust diagnostic and monitoring capabilities across different devices and operators, thereby enhancing their clinical utility