Clinical Publications

TRITON

Choroidal Thickness in Thyroid Eye Disease: Comparison With Controls and Application in Diagnosing Non-Inflammatory Active Disease

AUTHORS:

Dave TV, Natarajan R, Reddy RU, Kapoor AG, Dave VP

PUBLICATION:

Cureus 13(11): e19779. DOI: 10.7759/cureus.19779

Study Purpose

To report the differences in choroidal thickness in thyroid eye disease (TED) and normal and its discriminatory value for differentiating various stages of TED.

Overview

Study Design

Prospective, cross-sectional

# of Eyes/
Patients

• 102 eyes of 51 patients

Study Device

DRI Triton SS-OCT (Topcon, Tokyo, Japan)

Outcome Measures

• Central choroidal thickness and ETDRS sub-fields analysis for normal controls (C), inactive TED (I), active TED (A), non-inflammatory active TED (NIA) and systemic disorder but no TED (SYS)

Results

The central subfoveal choroidal thickness was significantly higher in the A group and NIA group than in the other ones.
For most of the ETDRS sub-fields choroidal thickness was significantly higher in the A and NIA group than in the C, I and SYS group.
At the choroidal thickness value of >226 microns, the central sub-field had the strongest discriminatory potential to predict active TED with a sensitivity of 75% and a specificity of 86.5%.
Age correlated negatively with choroidal thickness.
The CAS (clinical activity score) was positively correlated with increasing choroidal thickness

IMOvifa reduced measurement time by

39%

Conclusions

• This study showed that choroidal thickness was significantly higher in active TED and non-inflammatory active TED as compared to other groups (C, I, SYS). • Choroidal thickness may be of value in differentiating non-inflammatory active TED from inactive eyes, esp. as NIA eyes may not show clinical signs of activity and may have a low CAS.