Clinical Publications

TRITON

Ciliary muscle dimensions by swept-source optical coherence tomography and correlation study in a large population

AUTHORS:

Fernández-Vigo JI, Shi H, Kudsieh B, Arriola-Villalobos P, De-Pablo Gómez-de-Liaño L, García-Feijóo J, Fernández-Vigo JÁ.

PUBLICATION:

Acta Ophthalmol. 2020 Jun;98(4):e487-e494. DOI: 10.1111/aos.14304

Study Purpose

To examine ciliary muscle (CM) dimensions in vivo by swept-source optical coherence tomography (SS-OCT) in a large healthy population.

Overview

Study Design

Cross-sectional study

# of Eyes/
Patients

• 495 eyes from 495 subjects

Study Device

DRI OCT Triton™ (Topcon, Tokyo, Japan)

Outcome Measures

• CM length (CML), CM area (CMA) and CM thickness 1000 µm (CMT1), 2000 µm (CMT2) and 3000 µm (CMT3) from the scleral spur in the temporal and nasal quadrants. • Anterior chamber angle (ACA) and iris thickness 500 µm (IT500) from the scleral spur were also measured

Results

Mean CML was 4.57 ± 0.73 mm (range 2.16–6.97) and 4.45 ± 0.63 mm (2.42–6.37) in the temporal and nasal quadrants, respectively, with no differences detected between quadrants (p = 0.223).
Reproducibility of the CM measurements was excellent (ICC > 0.878)
Negative correlations were observed between refractive error and CML (R = -0.519; p < 0.001), and between refractive error and CM thickness (R ≥ -0.386; p < 0.001) or CMA (R = -0.538).
Negative correlations were found between CM dimensions (CML, CMT, and CMA) and age, with the strongest correlation observed for CML (R = -0.516; p < 0.001).
Ciliary muscle dimensions showed correlations with ACA (CML R = 0.499; CMT R = 0.434; CMA R = 0.545; all p < 0.001) and slightly with IOP (R = -0.175; p < 0.001) but no correlation was observed with IT500 (p ≥ 0.088)

IMOvifa reduced measurement time by

39%

FIGURE

FIGURE.

Swept-source optical coherence tomography ciliary muscle (CM) measurements made on a thick CM (upper image) and a thin CM (lower image). Adapted from Acta Ophthalmol. 2020 Jun;98(4):e487-e494. DOI: 10.1111/aos.14304

Conclusions

• This is the first study to use SS-OCT to assess CM dimensions in a large Caucasian population. • A SS-OCT instrument was used to measure CM dimensions with excellent reproducibility. • Data indicated a larger CB in myopia, a decrease produced with age, no correlation with gender, and good correlation with angle. • Limitations included, only assessing the horizontal quadrant, occasional difficulty determining the ciliary pigmented epithelium boundary, and the posterior zonules are not visible in the OCT images.