Clinical Publications

TEMPO

Comparison of the TEMPO Binocular Perimeter and Humphrey Field Analyzer

AUTHORS:

Nishida T, Weinreb R, Arias J, Vasile C, Moghimi S.

PUBLICATION:

Sci Rep. 2023 Dec 1;13(1):21189.

Study Purpose

To compare the TEMPO 24–2 Ambient Interactive Zippy Estimated by Sequential Testing (AIZE)-Rapid with the Humphrey field analyzer (HFA) 24–2 Swedish Interactive Threshold Algorithm (SITA)-Fast

Overview

Study Design

Prospective

# of Eyes/
Patients

740 eyes of 370 participants, including 68 healthy, 262 glaucoma suspects, and 410 glaucoma

Study Device

TEMPO binocular perimeter
Humphrey® field analyzer (HFA)
Cirrus® optical coherence tomography (OCT)

Outcome Measures

Visual field (VF) parameters, reliability indices, and coefficient of determinations for VF parameters and retinal nerve fiber layer (RNFL) thickness; measurement time and participant survey

Results

No significant differences were seen in mean deviation and visual field index between the two perimeters (P > 0.05), while significant differences were seen in pattern standard deviation and foveal threshold between TEMPO and HFA (both P < 0.001)
TEMPO AIZE-Rapid demonstrated lower values than HFA SITA-Fast for all reliability indices: fixation loss (11.2 [10.0, 12.5] % for HFA and 8.9 [7.3, 10.5] % for TEMPO), false positive (4.1 [3.7, 4.6] % for HFA and 1.3 [1.1, 1.5] % for TEMPO), and false negative (4.3 [3.8, 4.8] % for HFA and 0.4 [0.3, 0.4] % for TEMPO)
A stronger association between VF mean sensitivity (dB or 1/L) and
Stronger associations were found in the inferotemporal disc, followed by
Measurement time was faster for TEMPO compared to HFA
73% of participants preferred TEMPO while 17% preferred HFA. 83%

IMOvifa reduced measurement time by

39%

FIGURE 1

FIGURE 1.

Scatterplots showing associations between global VF mean sensitivity from TEMPO and HFA in dB scale (A, B) and unlogged 1/L scale (C, D), and circumpapillary retinal nerve fiber layer thickness.

Conclusions

TEMPO demonstrated a stronger structure–function association with Cirrus OCT compared to HFA, both globally and sectorally.