Clinical Publications

MAESTRO

Microaneurysms Detection by Two Optical Coherence Tomography Angiography Devices

AUTHORS:

Alibhai AY, Steffens T, Hou H, Durbin M, Waheed NK.

PUBLICATION:

Invest. Ophthalmol. Vis. Sci. 2024;65(7):5529.

Study Purpose

To evaluate detection of microaneurysms (MAs) in healthy and diseased eyes by two different OCTA devices, using fluorescein angiography (FA) as the gold standard

Overview

Study Design

Prospective

# of Eyes/
Patients

38 healthy eyes and 86 pathologic eyes, including diabetic retinopathy (DR), branch retinal vein occlusion, and exudative age-related macular degeneration

Study Device

Cirrus® (Zeiss, Dublin, CA) Maestro2 (Topcon Healthcare, Tokyo, Japan)

Outcome Measures

Positive percent agreement (PPA), or proportion of eyes with the OCTA showing microaneurysms (MAs) given the corresponding FA showed MAs; negative percent agreement (NPA), or proportion of eyes with the OCTA showing no MAs given the corresponding FA showed no MAs

Results

For healthy eyes, FA detected MAs in a few eyes, while OCTA observed none, meaning PPAs for the two devices and the three scan types were zero. The NPA were all 100%, except one macula 6mm x 6mm scan on the Cirrus revealed a false positive detection in one eye, reducing the corresponding NPA to 96.9%
For the eyes with pathology, the PPAs for MAs were all above 95% for the macular scan types on both OCTA devices and 73.9% and 70.0% for the disc scan for the Maestro and Cirrus, respectively. For both OCTA devices and all three scan types, the NPA ranged from 92.7% to 100% in eyes with pathologies

IMOvifa reduced measurement time by

39%

Conclusions

• No significant difference was seen between Maestro and Cirrus OCTA in identifying MAs. When comparing to the clinical gold standard FA, both had excellent performance in identifying MAs on or around the macula • The disc scan on both devices showed comparatively lower detection of MAs, suggesting that known limitations of OCTA technology, such as projection artifacts from the presence of bigger vessels, are more likely to obscure the identification of MAs in the circumpapillary area