Clinical Publications

MYAH

Non-invasive assessment of the tear film after LASIK

AUTHORS:

Yesilkaya E.C., Burke Z., Oksar M.T., Iritas I., Tanriverdi C., Karaca Y., Kilic A.

PUBLICATION:

Eur Rev Med Pharmacol Sci. 2023 Oct;27(19):9034-9042. doi: 10.26355/eurrev_202310_33928

Study Purpose

To assess noninvasive tear film measurements during the early postoperative period of LASIK using the keratoscopy-based MYAH device and to compare the results with those obtained using conventional methods

Overview

Study Design

Cross-sectional, single center observational study

# of Eyes/
Patients

80 eyes of 40 patients, mean age of 26.6 ± 5.9 years (18-40 years), who underwent bilateral primary LASIK

Study Device

MYAH (Topcon EU, Visia Imaging, Japan)

Outcome Measures

Tear film and ocular surface evaluation performed at baseline, postoperative week 1, and month 1. Measurements obtained using the Schirmer I test and invasive tear film breakup time (I-TBT) compared with non-invasive evaluation of the tear break up time (NITBT), tear meniscus height (TMH) and blink analysis obtained using the MYAH device [(Total TBT duration, first TBT, 5% level TBT, interblink interval (IBI), and ocular protection index (OPI)]

Results

There was a significant decrease in Schirmer I test between the preoperative and week 1 and month 1 postoperative examinations (19.21±8.4 vs. 16.61±9.1 vs. 14.69±9.86, p= 0.02, respectively
The results also revealed that there was a significant decrease between the preoperative and week 1 and month 1 postoperative examinations on I-TBT values (8.59 ± 3.4 vs.7.4 ± 3.25 vs. 6.17 ± 3.01, p= 0.03, respectively)
Significant reductions were seen in 5% NITBT at week 1 and month 1 from baseline. However, the total TBT duration and first TBT were not statistically different at all follow-up times
OPI decreased significantly at week 1 (p=0.009) and month 1 (p < 0.004)
No significant difference in the IBI score was detectable between the baseline and week 1 and month 1 (p = 0.124)
Although TMH increased non-significantly at week 1, the value was lower at month 1 compared to baseline (0.2 ±0.05 vs. 0.21 ± 0.05 vs. 0.18 ± 0.08, p= 0.04, respectively)

IMOvifa reduced measurement time by

39%

Conclusions

• This study showed that the objective non-invasive measurements of ocular surface metrics using the newly developed keratoscopy-based MYAH device provided useful, objective, and non-invasive data about the ocular surface after LASIK, though not all the measurements correlated with the class tests • The findings of this study demonstrate that the MYAH device can detect disruption of the ocular surface and tear film from 1-week to 1-month after surgery