Clinical Publications

MAESTRO

Optical Coherence Tomography Retinal Nerve Fibre Layer and Ganglion Cell Complex Measurements in Normal Southern Nigerian Eyes

AUTHORS:

Obasuyi OC, Osuji UE, Ifijen CO, Imafidon MA, Ovienria WA, Eguaojie IE, Eigbedion TE, Alikah AA.

PUBLICATION:

Cureus. 2022 Dec 29;14(12):e33101. doi: 10.7759/cureus.33101

Study Purpose

To provide the measurements of RNFL, GCL, and GCL+IPL in normal eyes of southern Nigerian patients and specifically to evaluate the relationship of these measurements to gender, age, intra-eye variability, and the Topcon SD-OCT normative database

Overview

Study Design

Cross-sectional retrospective

# of Eyes/
Patients

304 eyes of 152 patients

Study Device

Topcon 3D OCT-1 Maestro

Outcome Measures

Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and ganglion cell layer + inner plexiform layer (GCL + IPL)

Results

The male-to-female ratio was 1:1, and ages ranged between 18 and 71 for both genders
The average RNFL values were 111.49 ± 10.44 for the right eye (RE) and 111.96 ± 9.66 for the left eye (LE)
For the GCL, average values were 66.23 ± 4.4 (RE) and 66.34 ± 4.19 (LE). GCL+IPL values were 104.02 ± 6.71 (RE) and 103.89 ± 6.66 (LE)
There was no difference between genders (X2 = 56.467; df = 46; p = 0.160), and RNFL, GCL, and GCL+IPL values showed a significant reduction as the age of the respondents increased
There was a significant difference between RNFL, GCL, and GCL+IPL values and the Topcon reference database, p < 0.001

IMOvifa reduced measurement time by

39%

Conclusions

Significant differences exist between the Southern Nigerian eyes’ RNFL, GCL, and GCL+ IPL values and the Topcon 3D OCT-1 Maestro reference database, which should be considered while diagnosing and managing glaucoma with the OCT.