Clinical Publications

TRITON

Topographic patterns of retinal edema in eyes with branch retinal vein occlusion and their association with macular edema recurrence

AUTHORS:

Park HM, Kim YH, Lee BR, Ahn SJ.

PUBLICATION:

Sci Rep 11, 23249 (2021). DOI: 10.1038/s41598-021-02726-w

Study Purpose

Address the clinical implication of novel imaging technique for evaluating macular edema (ME) secondary to branch retinal vein occlusion (BRVO)

Overview

Study Design

Retrospective

# of Eyes/
Patients

• 87 eyes of 87 treatment naïve patients

Study Device

DRI Triton SS-OCT (Topcon, Tokyo, Japan)

Outcome Measures

• Topographic pattern of retinal edema • Retinal thickness • Rate of recurrence of ME after treatment • Subtype of BRVO: Major – occlusion of temporal arcade vein or branch extending to peripheral retinal beyond the retinal vascular arcades. Macular – occlusion confined between the superior and inferior retinal temporal vascular arcades

Results

Eyes with ME associated with BRVO included 49 and 38 eyes with superior and inferior RVO, respectively, and 37 and 50 eyes with macular and major BRVO, respectively.
Only 12 eyes (13.8%) with ME had retinal edema confined within the ETDRS grid. Most with ME (75, 86.2%) had combined macular and extramacular edema.
Edema patterns at 1 month after anti-VEGF therapy were significantly associated with the subtype of BRVO (P

IMOvifa reduced measurement time by

39%

Conclusions

• Residual edema following initial anti-VEGF therapy in the macular and extramacular areas, which could be identified using a widefield retinal thickness map, was significantly associated with recurrence of ME. • The authors stated that their results highlight the clinical usefulness of topographic analysis of retinal edema for the prediction of ME recurrence in patients with BRVO. • Monitoring and prediction of ME recurrence is important for long-term management of BRVO. • OCT is one of the most important imaging modalities for the evaluation and management of BRVO. It provides qualitative and quantitative assessments of the macula and, as a result, it is used extensively for the detection of BRVO-associated ME.